INSTITUTE
OF GENETICS & CYTOLOGY

National Academy of Sciences of Belarus

DNA DIAGNOSTICS FOR A HEREDITARY PREDISPOSITION TO CELIAC DISEASE (GLUTEN INTOLERANCE)

Celiac disease is a hereditary disease characterized by the atrophy of the small intestine mucosa caused by gluten intolerance.

To identify this intolerance, it is necessary to conduct a molecular analysis of the HLA-DQ2 gene since in 95% of cases gluten intolerance is associated with mutations in this particular gene. More than 97% of patients with celiac disease have such haplotype variants as HLA-DQ2 (DQA1*05/DQB1*02) or HLA-DQ8 (DQA1*03/DQB1*03).

As a result of DNA testing, you will find out whether you are a carrier of unfavorable mutations in the HLA-DQ2 gene (HLA-DQ2A1 and HLA-DQ2B1 loci). The presence of mutations in the HLA-DQ2 gene indicates a very high degree of a predisposition to celiac disease.

Indications for the study:

  • Allergy;
  • HLA-dependent celiac disease or gluten metabolism disorders in close relatives;
  • Autoimmune diseases;
  • Type 1 diabetes;
  • Low body mass index; and
  • Bowel disorders.

Full test fee:

88,00 BYN

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