Diabetes is a dangerous disease, widespread in developed countries, leading to disability and mortality. Type 2 diabetes is a metabolic multifactorial disease with a hereditary predisposition to it characterized by impaired insulin secretion or mechanisms of its interaction with tissue cells. Type 2 diabetes constitutes 85-90% of all the forms of diabetes and most often develops in people over 40 years of age, especially in the case of consuming large amounts of carbohydrates.
Metabolic disorders associated with polymorphisms in the genes TCF7L2, PPARG, KCNJ11 and UCP2, which affect the level of insulin in blood, lipoprotein metabolism, the development of metabolic syndrome, the division and differentiation of adipocytes and, under certain circumstances, increase or decrease the risk of disease development, play a key role in the pathogenesis of a disease. The detection of risk variants indicates the increased likelihood of type 2 diabetes. The level of risk is associated with age, increased body weight, hypodynamia, the increased intake of fast digesting carbs etc.
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27 Akademicheskaya St.
220072 Minsk
Belarus
