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Laboratory of Molecular Bases for Genome Stability

Head: Nadezhda Ryabokon

PhD (Biology)

E-mail: N.Ryabokon@igc.by

Key directions of scientific research:

  • Molecular-genetic bases of the integrity and stability of human and animal genomes in the norm, as well as under the influence of environmental factors and in pathological states;
  • Stability and variability of a genome; the impact of genome variability on general and reproductive health; oncogenomics: complex analysis of mutational and epigenetic variability of malignant tumors;
  • Improving diagnostics, a prognosis of the course of diseases and therapeutic approaches based on the study results of a genetic predisposition and molecular pathways of the pathogenesis of multifactorial diseases (autoimmune, oncological, reproductive etc.);
  • Antimutagenesis as an important way to maintain the integrity of a genome, to stimulate viability and to reduce the risk of morbidity.

Key publications:

  1. Translesion DNA synthesis and carcinogenesis / E.S. Shilkin [et al.] // Biochemistry. – 2020. – Vol. 85, No. 4. – P. 425–435.
  2. Polymorphism of proteasomal genes can be a risk factor for systemic autoimmune diseases in children / I.Y. Bakutenko [et al.] // Journal of Pediatric Genetics. – 2021. – Vol. 10, No. 2. – P. 98–104.
  3. Neutrophil cytosolic factor 2 (NCF2) gene polymorphism is associated with juvenile-onset systemic lupus erythematosus, but probably not with other autoimmune rheumatic diseases in children / I.Y. Bakutenko [et al.] // Molecular Genetics & Genomic Medicine. – 2022. – Vol. 10, No. 1. – e1859.
  4. Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives / E. Leonova [et al.] // Archives of Industrial Hygiene and Toxicology. – 2023. – Vol. 74. – P. 1–7.

Monographs:

  1. Genomic instability and DNA repair disruption as hereditary and somatic pathology factors of a human / R.I. Goncharova [et al.] ; under the general editorship of R.I. Goncharova. – Minsk : Bel. Navuka., 2015. – 282 p.

Instructions for use:

  1. A method for diagnosing of genetically determined forms of male infertility. Instruction for use. O.V. Pribusheniya, E.I. Golovataya, A.L. Markevich, E.A. Trebka, I.V. Naumchik, N.I. Ryabakon, N.V. Nikitchenko. The Ministry of Health of the Republic of Belarus. Regulations of March 18, 2016, No. 196-1115.
  2. An algorithm for predicting the outcomes of a bladder cancer treatment without muscle invasion. Instruction for use. M.P. Smal, A.I. Rolevich, T.I. Nabebina, S.A. Krasny, S.L. Polyakov, R.I. Goncharova. The Ministry of Health of the Republic of Belarus. Regulations of April 25, 2019, No. 012-0319.
  3. A method to assess the risk of metastasis and the unfavorable outcome of a disease in the case of muscle invasive bladder cancer by analyzing the methylation and allelic imbalance of genes involved in carcinogenesis. M.P. Smal, A.I. Rolevich, D.V. Bolshakova, L.N. Suslov, T.I. Nabebina, S.A. Krasny, R.I. Goncharova. The Ministry of Health of the Republic of Belarus. Registration No. 099-1021 of November 19, 2021.
  4. A method to determine the likelihood of the development of juvenile autoimmune rheumatic diseases. A.M. Chichko, G.M. Batyan, I.A. Kozyro, E.V. Sechko, S.I. Klechan, I.Yu. Bakutenko, I.D. Kuzhel, N.I. Ryabokon, A.V. Sukalo. The Ministry of Health of the Republic of Belarus. Registration No. 082-0622 of November 24, 2022.